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1 article(s) from Otto, Sijbren

Towards open-ended evolution in self-replicating molecular systems

Herman Duim and
Sijbren Otto

Beilstein J. Org. Chem. 2017, 13, 1189–1203, doi:10.3762/bjoc.13.118

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Graphical Abstract

Figure 1: Three processes involved in Darwinian evolution. Species must be replicated to obtain a large popul...

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Figure 2: Minimal system for self-replication. Building blocks A and B can react to form either template T or...

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Figure 3: A cross-catalytic replication scheme in which the formation of one template stimulates the formatio...

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Figure 4: The first oligonucleotide capable of template directed self-replication without the need of enzymes...

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Figure 5: Replication involving the SPREAD technique which prevents product inhibition. (1) A template molecu...

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Figure 6: Figure showing (a) a coiled coil motif due to hydrophobic interactions between hydrophobic amino ac...

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Figure 7: Self-replication of a helical peptide. Molecular recognition leads to the formation of a stable coi...

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Figure 8: (a) Cross-catalyzed replication of template molecules E and E’ from their building blocks A⁽’⁾ and B...

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Figure 9: Distribution of the species present in the reaction mixture after 20 serial transfers. E and E’ mol...

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Figure 10: (a) Secondary structure of the Azoarcus ribozyme consisting of four different strands of RNA, W, X,...

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Figure 11: (a) The different combinations of IGS strands, tags and break junction give rise to a total of 48 d...

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Figure 12: Figure depicting (a) building blocks consisting of a peptide attached to an aromatic ring. Building...

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Figure 13: Plot showing the relative concentrations of set I (red), set II (blue) and the link between them; (...

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Review

Published 21 Jun 2017

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